INTRODUCTION. Amiodarone is an iodinated benzofuran derivative that was synthesized and tested as an antianginal agent in the 1960s but was later discovered to have antiarrhythmic properties. Disopyramide (INN, trade names Norpace and Rythmodan) is an antiarrhythmic medication used in the treatment of ventricular tachycardia. It is a sodium channel blocker and therefore classified as a Class 1a anti-arrhythmic agent. DESCRIPTION. CORDARONE (amiodarone HCl) is an antiarrhythmic drug, available for oral administration as pink, scored tablets containing 200 mg of amiodarone hydrochloride. The complexity of coexistent heart failure and arrhythmia management warrants close collaboration between heart failure and arrhythmia specialists. 1 ml Amiodarone Hydrochloride 50 mg/ml Concentrate for Solution for Injection/Infusion contains 50 mg amiodarone hydrochloride equivalent to 46.9 mg amiodarone. It is recommended that the treating physician should be experienced in the management of chronic heart failure. Transient worsening of heart failure, hypotension, or bradycardia may occur during the titration 1 Major Outcomes in High-Risk Hypertensive Patients Randomized to Angiotensin-Converting Enzyme Inhibitor or Calcium Channel Bloc ker vs Diuretic. Pacerone ® (Amiodarone HCl) Tablets are a member of a class of antiarrhythmic drugs with predominantly Class III (Vaughan Williams' classification) effects, available for oral administration in 100 mg and 200 mg strengths of amiodarone hydrochloride. Amiodarone is used to treat certain types of serious irregular heartbeat. Learn about side effects, drug interactions, dosages, warnings, and more. Amiodarone hydrochloride tablets are indicated for the treatment of documented, life-threatening recurrent ventricular fibrillation and life-threatening recurrent hemodynamically unstable tachycardia in adults who have not responded to adequate doses of other available antiarrhythmics or when alternative agents cannot be tolerated.